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The active ingredient in Claritin is loratadin, in Allegra it's fexofenadine, and in Zyrtec it's cetirizine.

Consumer Reports reviewed all major allergy medications and found that monthly costs range considerably depending on which one you choose.

A common antihistamine used to treat seasonal allergies symptoms and the common cold, called clemastine fumarate, partially reversed damage to the visual system in people with multiple sclerosis (MS) in a preliminary study released in April 2016.© 72soul | Allergy sufferers have long faced a no-win situation with traditional antihistamine medications: sneeze and itch your way through seasonal allergies or take antihistamines and live in a fog instead.

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You just have to answer a couple of basic questions to figure out which to choose.

Of course, it is always a good idea to talk to your doctor before trying any new medication.

This may sound obvious, but the key thing to pay attention to is not what's written on a box, but what actually works for you.

"Some people may respond well to one anti-histamine while getting no benefit from another," Consumer Reports advises in its guide.

You can also find out whether any of your other medications will interact with Allegra, Claritin, or Zyrtec. The same antihistamine in Zyrtec, for example, is available as Aller-Tec at Costco, as Wal-Zyr at Walgreens, or even totally "unbranded" almost anywhere.

Just pay attention to labels so you know which active ingredient you're getting.

Sakina Bajowala, an Illinois-based allergist, explains. "They are all considered to be non-sedating or low-sedating anti-histamines (sic), and they are all very effective." That said, they do have some very slight differences — which probably aren't noticeable to every user. Claritin is long-acting, with effects that last for 24 hours.

Zyrtec acts the fastest — usually within one hour — but is also the most likely to make you drowsy, so avoid driving, alcohol, and sedatives as you figure out how you react.

The effects of these drugs on mood, daytime sleepiness, and some measures of sleep quality were assessed before and after one month of treatment.

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