Simply go through all the missions making the right choices to ensure you gain all character/story related trophies.
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You will still have all your cheated guns and ammo.
But it doesn't count as having cheats activated for that session. You will learn all the wonderful things about America, just some of it may be a lie since it's coming from your cousin Roman.
Just follow the route on your GPS and the mission will end with a cutscene showing the apartment and useful info about it. Or against Jacob if you want a challenge, he is quite good at pool. There are 15 balls (14 colored; 7 striped, and 7 solid) then there is the black 8 ball.
If your opponent pots a stripe, you are then by default solids, and it works the other way around if you hit first or the other color ball.
Just about every method, bug, and question is highlighted and addressed in this guide, making your multiplayer experience much easier.
For certain trophies, you can't have any cheats activated.
If there is anything that you may have missed, now is the time to go back and complete it.
Refer to Key To The City for a list of all that is necessary to achieve 100%.
This will take a little while, but at least you will also be working in lines with Key To The City.